Supramolecular
Materials & Biology
"from Molecules to Biology"
분자 자가조립 의약소재 연구실
Self-Assembly
친수성과 소수성을 지닌 양쪽성 분자의 자가 조립을 통해 소재를 제작.
Nano-machines
주어진 조건 하에서 모양과 기능을 바꿀 수 있는 나노 사이즈의 머신.
Host-Guest
호스트와 게스트 사이의 상호작용을 연구하고 응용하여 외부 환경 변화 감응 스마트 소재 연구.
Anti-Virus System
바이러스의 감염원리를 잘 이해하고, 이를 활용한 항바이러스 시스템 개발.
Peptide Materials
고체상 펩타이드 합성을 통해 다양한 펩타이드를 손쉽게 만들고 이를 활용한 생체 친화적 소재 제작.
DNA-based Materials
DNA 하이브리드 소재를 통해 유전 물질 전달 및 단백질 발현 조절.
Drug Delivery System
외부 자극 감응형 소재를 활용하여 원하는 타겟에 선택적으로 약물을 전달하는 시스템 개발.
Synthetic Membrane Channel
세포막을 통과하여 다양한 물질을 선택적으로 통과시킬 수 있는 스마트 인공채널 연구.
Organic Synthesis
유기 합성을 통해 기존에 없었던 새로운 분자 및 소재 개발.
Porous Sheet
We report the synthesis of homochiral porous nanosheets achieved by the 2D self-assembly of non-chiral macrocycles, with open/closed pore switching. Pore chirality is spontaneously induced by a twisted stack of dimeric macrocycles. The porous 2D structures can serve as enantiomer sieving membranes that exclusively capture a single enantiomer in a racemic mixture solution, with uptake capacity greater than 96%.
Nat. Mater. 2018, 17, 599.
DNA-Coat Assembly
We report a virus-like hierarchical assembly in which the native DNA and a synthetic coat undergo repeated collective helicity switching triggered by pH change under physiological conditions. We also show that this collective helicity inversion occurs during translocation of the DNA–coat assembly into intracellular compartments. Translating DNA conformational dynamics into a higher level of hierarchical dynamics may provide an approach to create DNA-based nanomachines.
Nat. Nanotechnol. 2017, 12, 551.
Dynamic Tubule
We report μm-long, dynamic tubular pores that undergo rapid switching between open and closed states in response to a thermal signal in water. Notably, this pore switching mediates a controlled water-pumping catalytic action for the dehydrative cyclization of adenosine monophosphate to produce metabolically active cyclic adenosine monophosphate. We believe that our work may allow the creation of a variety of dynamic pore structures with complex functions arising from open–closed motion.
Nat. Commun. 2015, 6, 8650.
Self-Assembly
Self-assembly is a process in which a disordered system of pre-existing components forms an organized structure or pattern as a consequence of specific, local interactions among the components themselves, without external direction. When the constitutive components are molecules, the process is termed molecular self-assembly.
Host-Guest
Host–guest chemistry describes complexes that are composed of two or more molecules or ions that are held together in unique structural relationships by forces other than those of full covalent bonds. Host–guest chemistry encompasses the idea of molecular recognition and interactions through non-covalent bonding. Non-covalent bonding is critical in maintaining the 3D structure of large molecules, such as proteins and is involved in many biological processes in which large molecules bind specifically but transiently to one another.
Supramolecular Immunomodulation
In this system, the strength and phenotype of the immune response can be modulated and optimized by systematically varying the epitope composition, a task that is greatly facilitated by the materials’ non-covalent construction.
서울특별시 성북구 안암로 145, 고려대학교, R&D센터, KU-KIST 융합대학원, 438D호
#438D, R&D Center, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea
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